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Francesco Papaleo

Senior Researcher Tenured - Principal Investigator
Genetics of Cognition
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Address
Research center
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About

EDUCATION / WORK EXPERIENCE

2019- present: Tenured Senior Researcher, Neuroscience Area, Istituto Italiano di Tecnologia, Genova, Italy.

2013- present: Adjunct Faculty Investigator, Lieber Institute for Brain Development. Baltimore, MD, USA.

2014- 2019: Senior Researcher, Associate Professor level, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova, Italy.

2011- 2014: Assistant Professor, Department of Pharmacological Sciences, University of Padova, Italy.

2010- 2014: Tenure Track-1, Team Leader, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova, Italy.

2005- 2010: Post Doctoral Fellow, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, USA. Supervisors: Dr. Daniel R. Weinberger and Dr. Jacqueline N. Crawley.

2004- 2004: Researcher, University of Bordeaux, France. Supervisors: Prof. Antoine Tabarin and Dr. Angelo Contarino.

2003- 2004: Researcher, INSERM Unit 588, “Laboratoire de Physiopathologie du Comportement”, Bordeaux, France. Supervisors: Dr. Pier Vincenzo Piazza and Dr. Angelo Contarino.

2002- 2005: PhD Student in Pharmacology and Toxicology, University of Padova, Italy. Supervisor: Dr. Angelo Contarino.

2000-  2001: Pharmacist. S. Chiara pharmacy. Vicenza, Italy. Supervisor: Dr. Paolo Pretto.

1996- 2001: Pharmacy graduate studies (110/110 cum Laude), University of Padova, Italy.


GRANTS

2022- 2025: Co-PI, work package leader. AIFA (Agenzia Italiana del Farmaco). Title: “Cannabidiol as an add-on treatment to substance abuse in juvenile patients with psychosis: a double-blind randomized placebo-controlled study (CAT-PSY)”.

2020- 2022: Principal Investigator. Research collaboration agreement with Friedrich Miescher Institute for Biomedical Research, Switzerland. Title: “Use of an innovative conditional D2-receptor knockout approach, coupled to time- and cell type-specific viral delivery to identify the critical targets in the mouse model LgDel”.

2020- 2024: Principal Investigator. Fondazione Telethon – project GGP19103, title: “Improving developmental trajectories in 22q11.2 deletion syndrome by oxytocin: focus on anti-inflammatory effects”.

2018- 2023: Principal Investigator. Ricerca Finalizzata Giovani Ricercatori 2016 - Ministero Salute – project GR-2016-02362413, title: “Dysbindin-antipsychotics psychophamarcogenetics: a mouse-human translational study towards personalized healthcare in bipolar disorders”.

2018- 2021: Principal Investigator. Boehringer Ingelheim Pharma. Title: “Role of the frontocortical-parvalbumin system in higher-order cognitive functions and in the onset of cognitive deficits induced by schizophrenia-relevant mutations”.

2018- 2020: Supervisor and hosting lab. Marie Sklodowska-Curie individual Fellowships to Celine Devroye. Grant N. 796244. SocialBrainCircuits.

2018: Principal Investigator. The MINDDS Action of the European COST Association (eCOST). Training school/hands-on workshop in “Convergence Neuroscience: bridging the gap between human patients and animal models of neurodevelopmental disorders”.

2016- 2018: Principal Investigator. Compagnia di San Paolo grant n. 2015-0321. Title: “Utilizzo di variazioni genetiche in dysbindin-1 (dtnbp1) per lo sviluppo di trattamenti più efficaci e personalizzati per la schizofrenia”.

2015- 2018: Principal Investigator. Brain & Behavior Research Foundation, 2015 NARSAD Independent Investigator grant n. 23234; Title: “Use of genetic-driven dysbindin-1 (DTNBP1) variations for more effective and personalized treatments in First Episode of Psychosis”.

2013- 2017: Principal Investigator. Roche Postdoc Fellowship Program; title: “D2L/S-dysbindin genetic interaction: towards early detection and personalized interventions for cognitive deficits and schizophrenia”.

2014- 2015: in charge of a work package. 2013 NARSAD Young Investigator grant. Title: “Indicated prevention with long-chain polyunsaturated omega-3 fatty acids in patients with 22q11 microdeletion syndrome genetically at high risk for psychosis: A randomised, double blind, placebo-controlled treatment trial”.

2013- 2016: Principal Investigator. Ricerca Finalizzata Giovani Ricercatori 2010 - Ministero Salute – project GR-2010-2315883, title: “Schizophrenia pathogenetic mechanisms associated to dysbindin dysfunctions in fly and mouse models”.

2010- 2014: Principal Investigator. Marie Curie FP7-Reintegration-Grants Call identifier: FP7-PEOPLE-2010-RG Grant n.268247 – SCHIZOGENES.

2008- 2010: Principal Investigator. NIHM Julius Axelrod Memorial Fellowship Training Award. Behavioral characterization of genetically modified mice for schizophrenia-associated susceptibility genes.


AWARDS AND HONORS

2018: Abilitazione Scientifica Nazionale, Full Professor, Fascia 1, Pharmacology.

2018: Scientific Director and Organizer of the Training school/hands-on workshop in “Convergence Neuroscience: bridging the gap between human patients and animal models of neurodevelopmental disorders”. Genova, Italy.

2017: travel award, ACNP 56th Annual Meeting, USA.

2017: Scientific Director and Organizer of the International Summer School of Neuroscience. Noto, Italy.

2015: Spring 2015 JOVE/Med Associates Competition.

2014: the Marie Curie Alumni Association.

2012: Winter Conference on Brain Research Travel Fellowship Award.

2009: Award as Preceptor, Howard Hughes Medical Institute Student Internship Program.

2008: NIMH Julius Axelrod Memorial Fellowship Training Award.

2008: Award as Preceptor, Howard Hughes Medical Institute Student Internship Program.

2007: Mentor to prize winner, American Academy of Neurology, Neuroscience Research Prize.


PROFESSIONAL SOCIETIES & SCIENTIFIC COMMITTEE

2018- : The Association for the Study of Animal Behaviour

2013- : Societa' Italiana di Farmacologia

2012- : Schizophrenia International Research Society

2012- : The Marie Curie Alumni Association

2008- : International Behavioral Neuroscience Society

2004- : Society for Neuroscience


2021- : Scientific Programme Committee, European College of Neuropsychopharmacology (ECNP)

2020- : Scientific Committeee of the IIT IACUC (Institutional Animal Care and Use Committee).


Education

Title: PhD Student in Pharmacology
Institute: University of Padova and University of Bordeaux
Location: Padova & Bordeaux
Country: Italy & France
From: 2002 To: 2005

Title: Pharmacy graduate studies
Institute: University of Padova
Location: Padova
Country: Italy
From: 1996 To: 2001

Experience External

Title: Post Doctoral Fellow
Institute: National Institute of Mental Health, NIH
Location: Bethesda
Country: USA
From: 2005 To: 2010

Top Publications
2022
Scheggia D., La Greca F., Maltese F., Chiacchierini G., Italia M., Molent C., Bernardi F., Carrano N., Zianni E., Gardoni F., Diluca M., Papaleo F.
Prosocial and selfish choices depend on cortico-amygdala reciprocal connections
Nature Neuroscience
Article in Press Journal
2020
Scheggia D., Manago F., Maltese F., Bruni S., Nigro M., Dautan D., Latuske P., Contarini G., Gomez-Gonzalo M., Requie L.M., Ferretti V., Castellani G., Mauro D., Bonavia A., Carmignoto G., Yizhar O., Papaleo F.
Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
Nature Neuroscience, vol. 23, (no. 1), pp. 47-60
Article Journal
All Publications
2022
Stuefer A., Balasco L., Bertozzi S., Coletta L., Hayward A., Rocchi F., Montani C., Alvino F., Galbusera A., Aldrighetti M., Gini S., Curcic V., Papaleo F., Iurilli G., Cancedda L., Armirotti A., Bozzi Y., Gozzi A.
Chemogenetic excitation of pyramidal neurons during early development: a longitudinal behavioral and imaging study
SfN
Poster Conference
2022
Pacinelli G., Managò F., Contarini G., Papaleo F.
Cortical Astrocytes Modulate Emotion Discrimination Through Cannabinoid System
FENS Forum 2022, Paris, France
Poster Conference
2022
Dautan D., Papaleo F.
Cortico-Cortical Transfer of Socially Derived Information Gates Emotion Discrimination
Optogenetic Approaches to Understanding Neural Circuits and Behavior. Gordon Research Conference. Newry, ME, USA
Poster Conference
2022
Mastrogiacomo R., Trigilio G., Devroye C., Dautan D., Ferretti V., Losi G., Caffino L., Orso G., Marotta R., Maltese F., Vitali E., Piras G., Forgiarini A., Pacinelli G., Lia A., Rothmond D.A., Waddington J.L., Drago F., Fumagalli F., Luca M.A.D., Leggio G.M., Carmignoto G., Weickert C.S., Manago F., Papaleo F.
Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia
Molecular Psychiatry
Article Journal
2022
Almacellas-Barbanoj A., Albini M., Satapathy A., Jaudon F., Michetti C., Krawczun-Rygmaczewska A., Huang H., Manago F., Papaleo F., Benfenati F., Cesca F.
Kidins220/ARMS modulates brain morphology and anxiety-like traits in adult mice
Cell Death Discovery, vol. 8, (no. 1)
Article Journal
Dissemination
2021
Papaleo F.
Genetics and psychiatric abnormalities in 22q11.2 deletion syndrome
Telethon patients associations
Outreach
2021
Papaleo f.
Neuroscience. Interview and research project events with SIAT (societa’ italiana analisi tecnica)
https://tradingdaycampus2021.siat.org/ and ManagerItalia Liguria
Public Event
2019
Papaleo F.
Disturbi Cognitivi: verso terapie ad personam.
Venerdi della cultura al CREAMCAFE. Genova, March 2019.
Outreach
2018
Papaleo F.
Clinical and preclinical translational research in psychiatric disorders.
Workshop in Precision Medicine for dysfunctions in cognitive and social processes.
Outreach
2018
Papaleo F.
“Marcatori genetici per la medicina personalizzata nelle psicosi e nelle schizofrenie”
Seminar for psychiatrists, medical doctors, nurses, patients’ and families’ associations. Organized by Kaleidos & iSPS Lombardia. Bergamo, June 2018.
Outreach
Scientific Talks
2022
Papaleo F.
Circuits of Emotion Discrimination
FENS Forum 2022, Paris, France
Conference
2022
Papaleo F.
Circuits of Emotion Discrimination
2022 Mediterranean Neuroscience Society, Dubrovnik, Croatia
Conference
2022
Papaleo F.
Cortico-Cortical Transfer of Socially Derived Information Gates Emotion Discrimination
EBPS Biennal Workshop, Roma, Italy
Workshop/Symposium
2022
Papaleo F.
Neural Circuits of Emotion Discrimination
Krasnoyarsk State Medical University, Russia
Institute
2022
Papaleo F.
Neural Circuits of Emotion Discrimination
CIMeC - Center for Mind/Brain Sciences, University of Trento
Institute
Awards and Achievements
2020
Papaleo F.
Committee scientific member of the IIT IACUC (Institutional Animal Care and Use Committee), or OPBA (Organismo preposto al benessere degli animali)
2018
Papaleo F.
Abilitazione Scientifica Nazionale, Full Professor, Fascia 1, Pharmacology
2017
Papaleo F.
travel award, ACNP 56th Annual Meeting, USA
2015
Papaleo F.
Spring 2015 JOVE/Med Associates Competition.
2014
Papaleo F.
the Marie Curie Alumni Association Travel Grant
Editorships
2012-2012
Papaleo F.
CNS & Neurological Disorders-Drug Targets
Organized Events
2021
Papaleo F.
Organizer and Scientific Programme Committee, the (European) Social Club Initiative
2021
Papaleo F.
Scientific Programme Committee, European College of Neuropsychopharmacology (ECNP)
2018
Papaleo F.
Training school/hands-on workshop in “Convergence Neuroscience: bridging the gap between human patients and animal models of neurodevelopmental disorders”
2017
Papaleo F.
Scientific Director and Organizer of the International Summer School of Neuroscience. Noto, Italy.