Zisis Bimpisidis

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Post doc

Research Lines



Zisis Bimpisidis was born in Orestiada, Greece, and studied Psychology and Neurosciences at the University of Crete. He obtained his PhD from the University of Cagliari at Gaetano Di Chiara’s lab where he studied the effects of substances of abuse on behavioral and neurochemical responses to taste stimuli, the interaction of cortical and subcortical dopaminergic systems during reward consumption, as well as the involvement of dopamine and endocannabinoid systems in substance use disorder.

He then moved to Sweden, at Prof. Angela Cenci’s group at Lund University, to investigate behavioral, pharmacological, molecular and neurovascular mechanisms involved in Parkinson’s Disease and treatment-induced dyskinesias using toxin based rat models of the disease.

After Lund, Zisis moved to Uppsala, Sweden, to join Prof Åsa Wallén-Mackenzie’s group. He pursued studies aiming to disentangle the heterogeneity of the midbrain dopamine systems, focusing on the cellular complexity of the Ventral Tegmental Area. He studied the circuitry involving dopamine, glutamate and co-releasing neurons and how they are mediating reward-related behaviors.

During his career Zisis has used a wide range of methodology to answer his scientific questions regarding the understanding of the biological substrate of behavior under normal conditions and disease. He joined Dr Francesco Papaleo’s GeCo lab at IIT, Genova, on October 2020 where he works to unravel the biological substrate of social behavior.


Dopamine Glutamate VTA Prefrontal cortex Basal ganglia Reinforcement Substance Use Disorder Schizophrenia

IIT Publications

  • 2020
  • Konig N., Bimpisidis Z., Dumas S., Wallen-Mackenzie A.

    Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse

    Frontiers in Behavioral Neuroscience, vol. 14
  • Bimpisidis Z., Konig N., Wallen-Mackenzie A.

    Two different real-time place preference paradigms using optogenetics within the ventral tegmental area of the mouse

    Journal of Visualized Experiments, vol. 2020, (no. 156)
  • 2019
  • Bimpisidis Z., Wallén-Mackenzie Å.

    Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder

    Journal of Clinical Medicine, vol. 8, (no. 11), pp. 1887
  • Bimpisidis Z., Konig N., Stagkourakis S., Zell V., Vlcek B., Dumas S., Giros B., Broberger C., Hnasko T.S., Wallen-Mackenzie A.

    The neuroD6 subtype of VTA neurons contributes to psychostimulant sensitization and behavioral reinforcement

    eNeuro, vol. 6, (no. 3)
  • 2018
  • Papathanou M., Creed M., Dorst M.C., Bimpisidis Z., Dumas S., Pettersson H., Bellone C., Silberberg G., Luscher C., Wallen-Mackenzie A.

    Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

    Frontiers in Neural Circuits, vol. 12
  • Bimpisidis Z., Fattore L., De Luca M.A.

    Taste novelty and dopamine

    Food Neophobia: Behavioral and Biological Influences, pp. 147-165, Publisher: Elsevier
  • 2017
  • Bimpisidis Z., Oberg C.M., Maslava N., Cenci M.A., Lundblad C.

    Differential effects of gaseous versus injectable anesthetics on changes in regional cerebral blood flow and metabolism induced by L-DOPA in a rat model of Parkinson's disease

    Experimental Neurology, vol. 292, pp. 113-124
  • Lerner R.P., Francardo V., Fujita K., Bimpisidis Z., Jourdain V.A., Tang C.C., Dewey S.L., Chaly T., Cenci M.A., Eidelberg D.

    Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia

    Scientific Reports, vol. 7, (no. 1)
  • 2016
  • Lerner R.P., Bimpisidis Z., Agorastos S., Scherrer S., Dewey S.L., Cenci M.A., Eidelberg D.

    Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model

    Neurobiology of Disease, vol. 96, pp. 31-37
  • Viereckel T., Dumas S., Smith-Anttila C.J.A., Vlcek B., Bimpisidis Z., Lagerstrom M.C., Konradsson-Geuken A., Wallen-Mackenzie A.

    Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease

    Scientific Reports, vol. 6
  • 2015
  • De Luca M.A., Lai F., Corrias F., Caboni P., Bimpisidis Z., Maccioni E., Fadda A.M., Di Chiara G.

    Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: Preparation and in vivo evaluation

    International Journal of Pharmaceutics, vol. 479, (no. 1), pp. 129-137
  • De Luca M.A., Bimpisidis Z., Melis M., Marti M., Caboni P., Valentini V., Margiani G., Pintori N., Polis I., Marsicano G., Parsons L.H., Di Chiara G.

    Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid

    Neuropharmacology, vol. 99, pp. 705-714
  • 2014
  • De Luca M.A., Valentini V., Bimpisidis Z., Cacciapaglia F., Caboni P., di Chiara G.

    Endocannabinoid 2-arachidonoylglycerol self-administration by Sprague-Dawley rats and stimulation of in vivo dopamine transmission in the nucleus accumbens shell

    Frontiers in Psychiatry, vol. 5, (no. OCT)
  • Fieblinger T., Sebastianutto I., Alcacer C., Bimpisidis Z., Maslava N., Sandberg S., Engblom D., Angela Cenci M.

    Mechanisms of dopamine D1 receptor-mediated ERK1/2 activation in the parkinsonian striatum and their modulation by metabotropic glutamate receptor type 5

    Journal of Neuroscience, vol. 34, (no. 13), pp. 4728-4740
  • 2013
  • Bimpisidis Z., De Luca M.A., Pisanu A., Di Chiara G.

    Lesion of medial prefrontal dopamine terminals abolishes habituation of accumbens shell dopamine responsiveness to taste stimuli

    European Journal of Neuroscience, vol. 37, (no. 4), pp. 613-622
  • Iderberg H., Rylander D., Bimpisidis Z., Cenci M.A.

    Modulating mGluR5 and 5-HT1A/1B receptors to treat l-DOPA-induced dyskinesia: Effects of combined treatment and possible mechanisms of action

    Experimental Neurology, vol. 250, pp. 116-124
  • 2012
  • De Luca M.A., Solinas M., Bimpisidis Z., Goldberg S.R., Di Chiara G.

    Cannabinoid facilitation of behavioral and biochemical hedonic taste responses

    Neuropharmacology, vol. 63, (no. 1), pp. 161-168
  • 2011
  • De Luca M.A., Bimpisidis Z., Bassareo V., Di Chiara G.

    Influence of morphine sensitization on the responsiveness of mesolimbic and mesocortical dopamine transmission to appetitive and aversive gustatory stimuli

    Psychopharmacology, vol. 216, (no. 3), pp. 345-353