Francesca Manago

Post Doc
Post-Doc

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Via Morego 30
+39 010 2896 857
0102896857

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About

Jenuary 2012 - present: Post Doc at the Neuroscience and Brain Technologies Department, Italian Institute of Technologies, Genoa, Italy. Supervisor: Dr. Francesco Papaleo

January 2011 - December 2011: research fellowship at the Neuroscience and Brain Technologies Department, Italian Institute of Technologies, Genoa, Italy. Supervisor: Dr. Raul R Gainetdinov. Director: Prof. Fabio Benfenati.

January 2008 - December 2010: Ph.D. student at the University of Genoa-Italian Institute of Technologies. Supervisor: Dr. Raul R Gainetdinov. Director: Prof. Fabio Benfenati.

November 2008 - May 2009: visiting graduate student at the Gastroenterology Department, Duke University, Durham NC, USA. Supervisor: Dr. Richard Premont.

May 2005 - December 2007: experimental research in the Laboratory of Psychobiology, Department of Genetic and Molecular Biology, University of Rome “La Sapienza” , Rome, Italy. Supervisors: Prof. Andrea Mele and Prof. Alberto Oliverio.

October 2006:               visiting student at "Laboratoire de Neurobiologie Cellulaire et Fonctionnelle”, Centre National de la Recherche Scientifique, Marseille, France. Supervisor: Dr. Marianne Amalric.

Selected Publications

  • Scheggia D*, Managò F*, Maltese F, Bruni S, Dautan D, Marco Nigro1, Patrick Latuske1,2, Gabriella Contarini1, Marta Gomez-Gonzalo3, Linda Maria Requie3, Valentina Ferretti1, Giulia Castellani1, Daniele Mauro1, Alessandra Bonavia1, Giorgio Carmignoto3, Ofer Yizhar4, Francesco Papaleo1*. Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice. Nature Neuroscience, under revision.
  • Leggio GM, Torrisi SA, Mastrogiacomo R, Mauro D, Chisari M, Devroye C, Scheggia D, Nigro M, Geraci F, Pintori N, Giurdanella G, Costa L, Bucolo C, Ferretti V, Sortino MA, Ciranna L, De Luca MA, Mereu M, Managò F, Salomone S, Drago F, Papaleo F. The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans. Mol Psychiatry. 2019 Sep 6. doi: 10.1038/s41380-019-0511-4
  • Ferretti V*, Maltese F*, Contarini G, Nigro M, Bonavia A, Huang H, Gigliucci V, Morella G, Schegga D, Managò F, Castellani G, Lefevre A, Cancedda L, Chini B, Grinevich V, Papaleo F. Oxytocin signaling in the central amygdala modulates emotion discrimination in mice. Curr Biol. 2019 Jun 17;29(12):1938-1953.e6. doi: 10.1016/j.cub.2019.04.070.
  • Szczurkowska J, Pischedda F, Pinto B, Managò F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L. NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice. Brain. 2018 Sep 1;141(9):2772-2794. doi: 10.1093/brain/awy190
  • Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nat Commun. 2018 Jun 11;9(1):2265. doi: 10.1038/s41467-018-04711-w
  • Managò F, Papaleo F. Schizophrenia: What's Arc Got to Do with It? Front Behav Neurosci. 2017 Sep 20;11:181. Review.
  • Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex. Mol Psychiatry. 2017 Jun 20.
  • Mereu M, Contarini G, Buonaguro EF, Latte G, Managò F, Iasevoli F, de Bartolomeis A, Papaleo F. Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder. Neuropharmacology. 2017 Jul 15;121:179-194.
  • Sannino S, Padula MC, Managò F, Schaer M, Schneider M, Armando M, Scariati E, Sloan-Bena F, Mereu M, Pontillo M, Vicari S, Contarini G, Chiabrera C, Pagani M, Gozzi A, Eliez S, Papaleo F. Adolescence is the starting point of sex-dichotomous COMT genetic effects. Transl Psychiatry. 2017 May 30;7(5):e1141.
  • Managò F, Huang H, Papaleo F. Modeling Cognitive Impairment. Handbook of Behavioral Neuroscience. Published on 01 Jan 2016
  • Managò F, Mereu M, Mastwal S, Mastrogiacomo R, Scheggia D, Emanuele M, De Luca MA, Weinberger DR, Wang KH, Papaleo F. Arc/Arg3.1 genetic disruption in mice causes dopamine system alterations and neurobehavioral phenotypes related to schizophrenia. Cell Rep. 2016 Aug 23;16(8):2116-28.
  • Sannino S, Gozzi A, Cerasa A, Piras F, Scheggia D, Managò F, Damiano M, Galbusera A, Erickson LC, De Pietri Tonelli D, Bifone A, Tsaftaris SA, Caltagirone C, Weinberger DR, Spalletta G, Papaleo F. COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans. Cereb Cortex. 2015 Sep;25(9):2529-41
  • Huang H, Michetti C, Busnelli M, Managò F, Sannino S, Scheggia D, Giancardo L, Sona D, Murino V, Chini B, Luisa Scattoni M, Papaleo F. Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice. Neuropsychopharmacology. 2014 Apr;39(5):1102-14. doi: 10.1038/npp.2013.310. Epub 2013 Nov 4.
  • Giancardo L, Sona D, Huang H, Sannino S, Managò F, Scheggia D, Papaleo F, Murino V. Automatic Visual Tracking and Social Behaviour Analysis with Multiple Mice. PLoS One. 2013 Sep 16;8(9):e74557.
  • Theka I, Caiazzo M, Dvoretskova E, Leo D, Ungaro F, Currelli S, Managò F , Dell’Anno MT, Pezzoli G, Gainetdinov RR, Dityatev A, Broccoli V. Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors. Stem Cells Transl Med. 2013 May 8.
  • Greco B, Managò F, Tucci V, Kao HT, Valtorta F, Benfenati F. Autism-related behavioral abnormalities in synapsin knockout mice. Behav Brain Res. 2012 Dec 29
  • Managò F, Lopez S, Oliverio A, Amalric M, Mele A, De Leonibus E. Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice. Psychopharmacology (Berl). 2013Apr;226(3):541-50.
  • Managò F., Espinoza S., Salahpour A., Sotnikova T.D., Caron M.G. Premont R.T., and Gainetdinov R.R. The role of GRK6 in animal models of Parkinson’s Disease and L-DOPA treatment. Sci Rep. 2012;2:301. Epub 2012 Mar 5.
  • Espinoza S., Managò F., Leo D., Sotnikova T.D., and Gainetdinov R.R. Role of Catechol-O-Methyltransferase (COMT)-dependent processes in Parkinson’s Disease and L-DOPA treatment. CNS Neurol Disord Drug Targets. 2012 May;11(3):251-63. Review.
  • De Leonibus E., Managò F., Giordani F., Petrosino F., Lopez S., Oliverio A., Amalric M., Mele A. Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson disease. Neuropsychopharmacology. 2009 Feb;34(3):729-38.
  • Managò F., Castellano C., Oliverio A., Mele A. and De Leonibus E. Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task. Learn Mem. 2008 Dec 30;16(1):46-52.

IIT Publications

  • 2020
  • Armando M., Ciampoli M.iit, Padula M.C., Amminger P., De Crescenzo F., Maeder J., Schneider M., Schaer M., Manago F.iit, Eliez S., Papaleo F.iit
    DOI

    Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome

    Neuropharmacology, vol. 168
  • Romano G.L., Platania C.B.M., Leggio G.M., Torrisi S.A., Giunta S., Salomone S., Purrello M., Ragusa M., Barbagallo C., Giblin F.J., Mastrogiacomo R.iit, Manago F.iit, Cammalleri M., Papaleo F.iit, Drago F., Bucolo C.
    DOI

    Retinal biomarkers and pharmacological targets for Hermansky-Pudlak syndrome 7

    Scientific Reports, vol. 10, (no. 1)
  • Espinoza S.iit, Scarpato M.iit, Damiani D.iit, Manago F.iit, Mereu M.iit, Contestabile A.iit, Peruzzo O.iit, Carninci P., Santoro C., Papaleo F.iit, Mingozzi F., Ronzitti G., Zucchelli S., Gustincich S.iit
    DOI

    SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson's Disease

    Molecular Therapy, vol. 28, (no. 2), pp. 642-652
  • Scheggia D.iit, Manago F.iit, Maltese F.iit, Bruni S.iit, Nigro M.iit, Dautan D.iit, Latuske P.iit, Contarini G.iit, Gomez-Gonzalo M., Requie L.M., Ferretti V.iit, Castellani G.iit, Mauro D.iit, Bonavia A.iit, Carmignoto G., Yizhar O., Papaleo F.iit
    DOI

    Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

    Nature Neuroscience, vol. 23, (no. 1), pp. 47-60
  • 2019
  • Ferretti V., Maltese F.iit, Contarini G., Nigro M., Bonavia A., Huang H., Gigliucci V., Morelli G., Scheggia D., Managò F.iit, Castellani G., Lefevre A., Cancedda L.iit, Chini B., Grinevich V., Papaleo F.iit

    Oxytocin signaling in the central amygdala modulates emotion discrimination in mice

    Current Biology
  • Ferretti V.iit, Maltese F.iit, Contarini G.iit, Nigro M.iit, Bonavia A.iit, Huang H.iit, Gigliucci V., Morelli G.iit, Scheggia D.iit, Manago F.iit, Castellani G.iit, Lefevre A., Cancedda L.iit, Chini B., Grinevich V., Papaleo F.iit
    DOI

    Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice

    Current Biology, vol. 29, (no. 12), pp. 1938-1953.e6
  • Scheggia D.iit, Managò F.iit, Maltese F., Bruni S., Nigro M., Dautan D., Latuske P., Contarini G., Gomez-Gonzalo M., Requie L.M., Ferretti V., Castellani G., Mauro D., Bonavia A., Carmignoto G., Yizhar O., Papaleo F.iit

    Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

    The Assembly and Function of Neuronal Circuits. Ascona, Switzerland
  • Scheggia D.iit, Managò F.iit, Maltese F.iit, Bruni S.iit, Nigro M.iit, Dautan D.iit, Latuske P.iit, Contarini G.iit, Gomez-Gonzalo M., Requie L.M., Ferretti V.iit, Castellani G.iit, Mauro D.iit, Bonavia A.iit, Carmignoto G., Yizhar O., Papaleo F.iit

    Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

    Nature Neuroscience
  • Leggio G.M., Torrisi S.A., Mastrogiacomo R.iit, Mauro D.iit, Chisari M., Devroye C.iit, Scheggia D.iit, Nigro M.iit, Geraci F., Pintori N., Giurdanella G., Costa L., Bucolo C., Ferretti V.iit, Sortino M.A., Ciranna L., De Luca M.A., Mereu M.iit, Manago F.iit, Salomone S., Drago F., Papaleo F.iit
    DOI

    The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans

    Molecular Psychiatry
  • 2018
  • Scheggia D.iit, Managò F.iit, Maltese F.iit, Bonavia A.iit, Nigro M.iit, Bruni S., Ferretti V.iit, Huang H.iit, Yizhar O., Papaleo F.iit

    Emotion recognition abilities rely on somatostatin interneurons activity in mouse prefrontal cortex.

    Gordon Research Conferences
  • Scheggia D.iit, Mastrogiacomo R.iit, Mereu M.iit, Sannino S.iit, Straub R.E., Armando M., Manago F.iit, Guadagna S.iit, Piras F., Zhang F., Kleinman J.E., Hyde T.M., Kaalund S.S., Pontillo M., Orso G., Caltagirone C., Borrelli E., De Luca M.A., Vicari S., Weinberger D.R., Spalletta G., Papaleo F.iit
    DOI

    Erratum to: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment (Nature Communications, (2018), 9, 1, (2265), 10.1038/s41467-018-04711-w)

    Nature Communications, vol. 9, (no. 1)
  • Szczurkowska J.iit, Pischedda F., Pinto B.iit, Manago F.iit, Haas C.A., Summa M.iit, Bertorelli R.iit, Papaleo F.iit, Schafer M.K., Piccoli G., Cancedda L.iit
    DOI

    NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice

    Brain, vol. 141, (no. 9), pp. 2772-2794
  • Scheggia D.iit, Zamberletti E., Realini N.iit, Mereu M.iit, Contarini G., Ferretti V.iit, Manago F.iit, Margiani G., Brunoro R.iit, Rubino T., De Luca M.A., Piomelli D.iit, Parolaro D., Papaleo F.iit
    DOI

    Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex

    Molecular Psychiatry, vol. 23, (no. 4), pp. 1040-1050
  • Scheggia D.iit, Mastrogiacomo R.iit, Mereu M.iit, Sannino S.iit, Straub R.E., Armando M., Manago F.iit, Guadagna S.iit, Piras F., Zhang F., Kleinman J.E., Hyde T.M., Kaalund S.S., Pontillo M., Orso G., Caltagirone C., Borrelli E., De Luca M.A., Vicari S., Weinberger D.R., Spalletta G., Papaleo F.iit
    DOI

    Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

    Nature Communications, vol. 9, (no. 1)
  • 2017
  • Sannino S.iit, Padula M.C., Manago F.iit, Schaer M., Schneider M., Armando M., Scariati E., Sloan-Bena F., Mereu M.iit, Pontillo M., Vicari S., Contarini G., Chiabrera C.iit, Pagani M.iit, Gozzi A.iit, Eliez S., Papaleo F.iit
    DOI

    Adolescence is the starting point of sex-dichotomous COMT genetic effects

    Translational Psychiatry, vol. 7, (no. 5)
  • Mereu M., Contarini G., Buonaguro E.F., Latte G., Manago F.iit, Iasevoli F., de Bartolomeis A., Papaleo F.iit
    DOI

    Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder

    Neuropharmacology, vol. 121, pp. 179-194
  • Manago F.iit, Papaleo F.iit
    DOI

    Schizophrenia: What’s arc got to do with it?

    Frontiers in Behavioral Neuroscience, vol. 11
  • 2016
  • Manago F.iit, Mereu M., Mastwal S., Mastrogiacomo R.iit, Scheggia D.iit, Emanuele M.iit, De Luca M.A., Weinberger D.R., Wang K.H., Papaleo F.iit
    DOI

    Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia

    Cell Reports, vol. 16, (no. 8), pp. 2116-2128
  • Manago F.iit, Huang H.iit, Francesco P.iit
    DOI

    Modeling Cognitive Impairment

    Handbook of Behavioral Neuroscience, vol. 23, pp. 69-84
  • 2015
  • Sannino S.iit, Gozzi A.iit, Cerasa A., Piras F., Scheggia D.iit, Manago F.iit, Damiano M.iit, Galbusera A.iit, Erickson L.C., De Pietri Tonelli D.iit, Bifone A.iit, Tsaftaris S.A., Caltagirone C., Weinberger D.R., Spalletta G., Papaleo F.iit
    DOI

    COMT genetic reduction produces sexually divergent effects on cortical anatomy and working memory in mice and humans

    Cerebral Cortex, vol. 25, (no. 9), pp. 2529-2541
  • 2014
  • Huang H.iit, Michetti C., Busnelli M., Manago F.iit, Sannino S.iit, Scheggia D.iit, Giancardo L.iit, Sona D.iit, Murino V.iit, Chini B., Scattoni M.L., Papaleo F.iit
    DOI

    Chronic and acute intranasal oxytocin produce divergent social effects in mice

    Neuropsychopharmacology, vol. 39, (no. 5), pp. 1102-1114
  • 2013
  • Greco B.iit, Manago F.iit, Tucci V.iit, Kao H.-T., Valtorta F., Benfenati F.iit
    DOI

    Autism-related behavioral abnormalities in synapsin knockout mice

    Behavioural Brain Research, vol. 251, pp. 65-74
  • Giancardo L.iit, Sona D.iit, Huang H.iit, Sannino S.iit, Manago F.iit, Scheggia D.iit, Papaleo F.iit, Murino V.iit
    DOI

    Automatic Visual Tracking and Social Behaviour Analysis with Multiple Mice

    PLoS ONE, vol. 8, (no. 9)
  • Manago F., Lopez S., Oliverio A., Amalric M., Mele A., De Leonibus E.
    DOI

    Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice

    Psychopharmacology, vol. 226, (no. 3), pp. 541-550
  • Theka I., Caiazzo M., Dvoretskova E.iit, Leo D.iit, Ungaro F., Curreli S.iit, Manago F.iit, Dell'Anno M.T., Pezzoli G., Gainetdinov R.R.iit, Dityatev A.iit, Broccoli V.
    DOI

    Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors

    Stem cells translational medicine, vol. 2, (no. 6), pp. 473-479
  • 2012
  • Espinoza S.iit, Manago F.iit, Leo D.iit, Sotnikova T.D.iit, Gainetdinov R.R.iit
    DOI

    Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment

    CNS and Neurological Disorders - Drug Targets, vol. 11, (no. 3), pp. 251-263
  • Manago F.iit, Espinoza S.iit, Salahpour A., Sotnikova T.D.iit, Caron M.G., Premont R.T., Gainetdinov R.R.iit
    DOI

    The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment

    Scientific Reports, vol. 2
  • 2009
  • De Leonibus E., Manago F., Giordani F., Petrosino F., Lopez S., Oliverio A., Amalric M., Mele A.
    DOI

    Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease

    Neuropsychopharmacology, vol. 34, (no. 3), pp. 729-738
  • Manago F., Castellano C., Oliverio A., Mele A., De Leonibus E.
    DOI

    Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task

    Learning and Memory, vol. 16, (no. 1), pp. 46-52

Awards

SINS fellowships for young Italian neuroscientists to attend the 8th IBRO World Congress of Neuroscience (in Florence, 2011).

Hello Bio travel award to attend at the IBNS 2019 in Cairns, Australia.